| Fase Preliminar | ||||||
| 20/8/80 | Esmirna | Altay | 0 | |||
| Benfica | 0 | |||||
| 3/9/80 | Lisboa | Benfica | 4 | Chalana, Humberto, Nene, Cesar | ||
| Altay | 0 | |||||
| 20/8/80 | Glasgow | Celtic | 6 | McGarvey (2), McCluskey (2), Szanto (A), Sullivan | ||
| Diosgyori | 0 | |||||
| 3/9/80 | Miskolc | Diosgyori | 2 | Gorgei (2) | ||
| Celtic | 1 | Nicholas | ||||
| 1º Fase | ||||||
| 16/9/80 | Sofia | Slavija | 3 | Tsvetkov (P), Velichkov (2) | ||
| Legia | 1 | Miloszewicz | ||||
| 1/10/80 | Varsovia | Legia | 1 | Okonski (P) | ||
| Slavija | 0 | |||||
| 16/9/80 | Luxemburgo | Spora | 0 | |||
| Sparta | 6 | Berger (2), Kotek, Chaloupka (2), Baumert (A) | ||||
| 1/10/80 | Praga | Sparta | 6 | Pospisil, Slany, Jarolim (2), Berger, Horvath | ||
| Spora | 0 | |||||
| 16/9/80 | Newport | Newport County | 4 | Gwyther, Moore, Aldridge, Burton | ||
| Crusaders | 0 | |||||
| 1/10/80 | Belfast | Crusaders | 0 | |||
| Newport County | 0 | |||||
| 17/9/80 | Copenhague | Hvidore | 1 | Hansen | ||
| Fram | 0 | |||||
| 28/9/80 | Reykjavik | Fram | 0 | |||
| Hvidore | 2 | Ambrose, Hansen | ||||
| 17/9/80 | Madrid | Castilla | 3 | Paco, Balin, Cidon | ||
| West Ham | 1 | Cross | ||||
| 1/10/80 | Londres | West Ham | 5 | Pike, Cross (3), Goddard | ||
| Castilla | 1 | Bernal | ||||
| 17/9/80 | Levkosia | Omonia | 1 | Kanaris | ||
| Thor | 3 | Van Poucke, Hanssen, Meds | ||||
| 1/10/80 | Waterschei | Thor | 4 | Janssen, Plessers (P), Van Poucke (2) | ||
| Omonia | 0 | |||||
| 17/9/80 | Sion | Sion | 1 | Brigger | ||
| Haugar | 1 | Osborne | ||||
| 1/10/80 | Haugesund | Haugar | 2 | Nilsen, Christoffersen (P) | ||
| Sion | 0 | |||||
| 17/9/80 | Glasgow | Celtic | 2 | Nicholas (2) | ||
| Politehnica | 1 | Adrian | ||||
| 1/10/80 | Timisoara | Politehnica | 1 | Paltinisan | ||
| Celtic | 0 | |||||
| 17/9/80 | Zagreb | Dinamo Zagreb | 0 | |||
| Benfica | 0 | |||||
| 1/10/80 | Lisboa | Benfica | 2 | |||
| Dinamo Zagreb | 0 | |||||
| 17/9/80 | Dusseldorf | Fortuna | 5 | Konnen (2), Wenzel, K. Allofs, Dusend | ||
| Casino | 0 | |||||
| 1/10/80 | Salzburgo | Casino | 0 | |||
| Fortuna | 3 | T. Allofs, Dusend (2) | ||||
| 17/9/80 | Paola | Hibernians | 1 | Xuereb | ||
| Waterford | 0 | |||||
| 1/10/80 | Waterford | Waterford | 4 | Kirk (2), Finucane, Fitzpatrick | ||
| Hibernians | 0 | |||||
| 17/9/80 | Kastoria | Kastoria | 3 | |||
| Dinamo Tbilisi | 0 | |||||
| 1/10/80 | Tbilisi | Dinamo Tbilisi | 2 | Shengelia, Gutsaev | ||
| Kastoria | 0 | |||||
| 17/9/80 | Malmo | Malmo | 1 | McKinnon | ||
| Partizani | 0 | |||||
| 1/10/80 | Tirana | Partizani | 0 | |||
| Malmo | 0 | |||||
| 17/9/80 | Roma | Roma | 3 | Pruzzo, Ancelotti, Falcao | ||
| Carl Zeiss | 0 | |||||
| 1/10/80 | Jena | Carl Zeiss | 4 | Krause, Lindemann, Bielau (2) | ||
| Roma | 0 | |||||
| 17/9/80 | Tampere | Ilves | 1 | Uimonen | ||
| Feyenoord | 3 | Notten (P), Van Deinsen, Troost | ||||
| 1/10/80 | Rotterdam | Feyenoord | 4 | Vermeulen, Nielsen, Troost, Notten | ||
| Ilves | 2 | Prinen (P), Wacklin | ||||
| 17/9/80 | Valencia | Valencia | 2 | Kempes, Morena (P) | ||
| Monaco | 0 | |||||
| 1/10/80 | Montecarlo | Monaco | 3 | Petit (2), Barberis | ||
| Valencia | 3 | Morena, Kempes, Felman | ||||
| 2º Fase | ||||||
| 22/10/80 | Haugesund | Haugar | 0 | |||
| Newport County | 0 | |||||
| 4/11/80 | Newport | Newport County | 6 | Gwyther, Lowndes, Aldridge, Tynan (2), Moore | ||
| Haugar | 0 | |||||
| 22/10/80 | Jena | Carl Zeiss | 3 | Sengewald, Schnuphase (P), Trocha | ||
| Valencia | 1 | Morena | ||||
| 5/11/80 | Valencia | Valencia | 1 | Botubot | ||
| Carl Zeiss | 0 | |||||
| 22/10/80 | Copenhague | Hvidore | 1 | Manniche | ||
| Feyenoord | 2 | Wijnstekers, Bouwens | ||||
| 5/11/80 | Rotterdam | Feyenoord | 1 | Nielsen | ||
| Hvidore | 0 | |||||
| 22/10/80 | Malmo | Malmo | 1 | Andersson | ||
| Benfica | 0 | |||||
| 5/11/80 | Lisboa | Benfica | 2 | Nene (2P) | ||
| Malmo | 0 | |||||
| 22/10/80 | Praga | Sparta | 2 | Vdovjak (2) | ||
| Slavija | 0 | |||||
| 5/11/80 | Sofia | Slavija | 3 | Velichkov, Zelazkov, Tsvetkov | ||
| Sparta | 0 | |||||
| 22/10/80 | Waterford | Waterford | 0 | |||
| Dinamo Tbilisi | 1 | Shengelia | ||||
| 5/11/80 | Tbilisi | Dinamo Tbilisi | 4 | Daraselia (2), Chivadze, Chilaia | ||
| Waterford | 0 | |||||
| 22/10/80 | Waterschei | Waterschei | 0 | |||
| Fortuna | 0 | |||||
| 5/11/80 | Dusseldorf | Fortuna | 1 | Bansemer | ||
| Waterschei | 0 | |||||
| 22/10/80 | Londres | West Ham | 4 | Bonds, Goddard, Stewart (P), Cross | ||
| Politehnica | 0 | |||||
| 5/11/80 | Timisoara | Politehnica | 1 | Paltinisan | ||
| West Ham | 0 | |||||
| CUARTOS DE FINAL | ||||||
| 4/3/81 | Jena | Carl Zeiss | 2 | Raab (2) | ||
| Newport County | 2 | Tynan (2) | ||||
| 18/3/81 | Newport | Newport County | 0 | |||
| Carl Zeiss | 1 | Kurbjuweit | ||||
| 4/3/81 | Dusseldorf | Fortuna | 2 | Wenzel, Dusend | ||
| Benfica | 2 | Carlos Manuel, Humberto | ||||
| 18/3/81 | Lisboa | Benfica | 1 | Chalana | ||
| Fortuna | 0 | |||||
| 4/3/81 | Sofia | Slavija | 3 | Tsvetkov (2, 1P), Illiev | ||
| Feyenoord | 2 | Nielsen, Vermeulen | ||||
| 18/3/81 | Rotterdam | Feyenoord | 4 | Notten, Van Deinsen, Vermeulen, Bouwens | ||
| Slavija | 0 | |||||
| 4/3/81 | Londres | West Ham | 1 | Cross | ||
| Dinamo Tbilisi | 4 | Chivadze, Gutsaev, Shengelia (2) | ||||
| 18/3/81 | Tbilisi | Dinamo Tbilisi | 0 | |||
| West Ham | 1 | Pearson | ||||
| SEMIFINALES | ||||||
| 8/4/81 | Jena | Carl Zeiss | 2 | Bielau, Raab | ||
| Benfica | 0 | |||||
| 22/4/81 | Lisboa | Benfica | 1 | Reinaldo | ||
| Carl Zeiss | 0 | |||||
| 8/4/81 | Tbilisi | Dinamo Tbilisi | 3 | Sulakvelidze (2), Gutsaev | ||
| Feyenoord | 0 | |||||
| 22/4/81 | Rotterdam | Feyenoord | 2 | Bouwens, Notten (P) | ||
| Dinamo Tbilisi | 0 | |||||
| FINAL | ||||||
| 13/5/81 | Dusseldorf | Dinamo Tbilisi | 2 | Gutsaev, Daraselia | ||
| Carl Zeiss | 1 | Hoppe | ||||
| Campeón: Dinamo Tbilisi (Union Sovietica) | ||||||